Molecular cloning and functional expression of a rabbit renal organic cation transporter
نویسندگان
چکیده
منابع مشابه
Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1.
Multiple organic cation transporters (OCTs) are present in rabbit kidney and may play different functional roles. We cloned rabbit OCT2 (rbOCT2) and compared its function with that of rabbit OCT1 (rbOCT1). In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [3H]tetraethylammonium (TEA) with K(t) values of 188 and 125 microM, respectively. n-Tetraalkylammonium compounds ...
متن کاملMolecular Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1
Cloning of the Rabbit Organic Cation Transporter, rbOCT2, and Functional Comparisons with rbOCT1. Am J. Physiol. Renal Physiol. Multiple organic cation (OC) transporters are present in rabbit kidney and may play different functional roles. We cloned rbOCT2 and compared its function with that of rbOCT1. In transiently transfected COS-7 cells, rbOCT1 and rbOCT2 mediated uptake of [ 3 H]tetraethyl...
متن کاملCloning and functional expression of a human liver organic cation transporter.
Polyspecific organic cation transporters in the liver mediate the elimination of a wide array of endogenous amines and xenobiotics. In contrast to our understanding of the mechanisms of organic cation transport in rat liver, little is known about the mechanisms of organic cation transport in the human liver. We report the cloning, sequencing, and functional characterization of the first human p...
متن کاملSex differences in the mRNA, protein, and functional expression of organic anion transporter (Oat) 1, Oat3, and organic cation transporter (Oct) 2 in rabbit renal proximal tubules.
Sex differences in transport of the organic anion (OA) substrate p-aminohippurate (PAH) and the organic cation (OC) substrate tetraethylammonium (TEA) have been recognized for some time. In the rat kidney, androgens up-regulate and estrogens down-regulate PAH and TEA transport, which correlate with similar changes in mRNA and protein expression for the renal basolateral membrane transporters or...
متن کاملMolecular cloning and functional expression of a multispecific organic anion transporter from human kidney.
Recently, we isolated the multispecific organic anion transporter (OAT1) from the rat kidney, which plays important roles in the renal elimination of endogenous and exogenous organic anions including clinically important drugs. In the present study, we cloned and characterized human OAT1. Two cDNA clones, hOAT1-1 cDNA and hOAT1-2 cDNA, were isolated from a human kidney cDNA library, whose amino...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1998
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(97)00207-1